305 Overlaps between inflammatory dermatoses and ichthyoses: need for novel therapeutic approaches

Ichthyoses form a heterogeneous group of well-defined inherited skin diseases. However, the comorbidity these cornification disorders needs to be further investigated, as psoriasiform lesions and/or atopic manifestations may observed in many affected individuals. We recruited 64 patients with ichthyoses, 29 psoriasis and 37 dermatitis (AD) patients, assessed disease severity by Ichthyosis Area Severity Index (IASI; 0-48) pruritus characteristics Neuroderm Questionnaire. Further, we performed immunohistochemical stainings CCL27, Nos2, filaggrin, β-defensin-2 CD1a on 15 samples ichthyoses compared them AD. In ichthyosis median was 8 highest scores Netherton syndrome (NTS). Generalized occurred 84% intensity 3 numeric rating scale (0-10). 13% described neuropathic itch qualities showed an impaired quality life due itch. Of note, almost 50% systemic therapy still moderate pruritus. AD significantly higher than (p ≤ 0,01). Staining CCL27 Nos2 revealed psoriasis-like phenotype more patients. Filaggrin deficiency not only vulgaris (IV), but also congenital X-linked ichthyosis. ß-defensin-2 present some samples, there were two (IV XLI) high levels CD1a. Atopic diathesis prevalent IV NTS, among all subtypes. conclude that immunological characterization according or diathese pattern could improve treatment disease. Novel targeted therapies subject future clinical studies itch, inflammation probably scaling.